Peripheral nervous system involvement in HCV-related mixed cryoglobulinemia

Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia

PURPOSE To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. METHODS Case report and literature review. RESULTS A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his right eye, associated with redness and photophobia. Medical background elicited a history of Hep...

HCV-Related Central and Peripheral Nervous System Demyelinating Disorders

Chronic infection with hepatitis C virus (HCV) is associated with a large spectrum of extrahepatic manifestations (EHMs), mostly immunologic/rheumatologic in nature owing to B-cell proliferation and clonal expansion. Neurological complications are thought to be immune-mediated or secondary to invasion of neural tissues by HCV, as postulated in transverse myelitis and encephalopathic forms. Prim...

HCV-Related Nervous System Disorders

Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immun...

Assessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemia

INTRODUCTION In hepatitis C virus (HCV)-related mixed cryoglobulinemia (MCG), the nonenveloped HCV core protein (HCV-Cp) is a constituent of the characteristic cold-precipitating immune complexes (ICs). A possible correlation between HCV-Cp, virologic, laboratory, and clinical parameters in both untreated MCG patients and those undergoing specific treatment was explored. METHODS HCV-Cp was qu...

HCV, Mixed Cryoglobulinemia and Malignant Lymphoproliferation